Mayer, C.T. et al. The microanatomic segregation of selection by apoptosis in the germinal center. Sort by citations Sort by year Sort by title. The answer may be a nuanced “no.”, COVID-19 immunology study reveals universally effective antibodies, Scientists are using ‘elite’ antibodies from COVID-19 survivors to develop potent therapies. Now Michel Nussenzweig works on curing COVID-19, in a recent Nature paper, by studying virus-neutralising antibodies. The immune system protects vertebrates from a multitude of pathogens. Protein amounts of the MYC transcription factor determine germinal center B cell division capacity. Cell 169, 597–609 (2017). A second focus of Nussenzweig’s lab is on dendritic cells, which elicit adaptive immune responses by taking up antigens and presenting them to lymphocytes. Their son Michel studied, graduated and built his entire academic career at the neighbouring Rockefeller University, where his faculty chair is named by his two famous PhD mentors, Zanvil Cohn and Ralph Steinman. Adaptive immune responses are primarily carried out by cells called lymphocytes, which produce a diverse repertoire of immune receptors that recognize almost any antigen. Nussenzweig has isolated such broadly neutralizing antibodies from HIV-infected patients whose immune systems had an exceptional ability to neutralize HIV in the blood. Nussenzweig’s research aims to understand the rules that govern hypermutation and high affinity antibody selection, with the goal of creating vaccines for pathogens such as HIV-1. Nussenzweig is a faculty member in the David Rockefeller Graduate Program, and the Tri-Institutional M.D.-Ph.D. Nussenzweig’s laboratory investigates the molecular basis of such hypermutation, and the selection for high affinity antibody-producing cells in the germinal center. HHMI, The Rockefeller University. This work has helped establish a new paradigm for developing vaccines and therapies for infectious diseases. And unlike traditional antiretroviral therapy, which requires daily dosing, the antibodies continue to provide protection and treatment for months after they have been administered, suggesting they might lead to long-term control of the virus. Kirby Center for Sensory Neuroscience, Pels Family Center for Biochemistry and Structural Biology, Shelby White and Leon Levy Center for Mind, Brain and Behavior, Center for Clinical and Translational Science. Copyright 2004—2020 The Rockefeller University. This paradigm has been extended to other viruses such as hepatitis B and flaviviruses. Recently, the lab defined distinct progenitor lineages for classical spleen dendritic cells, plasmacytoid dendritic cells, and monocytes, a step toward antigen-specific targeting. Verified email at Mendoza, P. et al. Combination therapy with anti-HIV-1 antibodies maintains viral suppression. Nussenzweig’s laboratory investigates the molecular basis of such hypermutation, and the selection for high affinity antibody-producing cells in the germinal center. Nussenzweig’s experiments are consistent with the notion that self-antigens taken up by dendritic cells induce tolerance, whereas antigens taken up in the context of activation stimuli, such as those found during inflammation or tissue destruction, induce prolonged T cell activation. Nature 570, 468–473 (2019). Scientists hope to deploy antibodies in the quest to end COVID-19. Program. His work is leading to new antibody-based therapies for infections by HIV and the novel SARS-CoV-2 coronavirus, among other viruses. Rockefeller University immunologist Michel Nussenzweig and his colleagues launched a study of people who have recovered from coronavirus infections this … Current studies focus on outlining the pathway of human dendritic cell development and differentiation. Articles Cited by Co-authors. Escolano, A. et al. The ability to target antigens to dendritic cells and control their function in vivo has significant implications for the development of vaccines and therapies for autoimmunity. Gabriel D Victora Laurie and Peter Grauer Assistant Professor and Head, Laboratory of Lymphocyte Dynamics, The Verified email at Meet the scientific leaders who are changing medicine, Peek inside our 70 biomedical laboratories, Learn more about our flexible, supportive academic programs, Learn about the breakthroughs happening every day, Hear from the world’s leading speakers and thinkers, We’ve spent 119 years perfecting the bioscience institute, Will SARS-CoV-2 escape future drugs by mutating? Clinical Research and the Rockefeller University Hospital, Chemers Neustein Summer Undergraduate Research Fellowship Program, Experience Science, the Arts, and Culture. Nussenzweig’s laboratory studies the molecular aspects of the immune system’s innate and adaptive responses using a combination of biochemistry, molecular biology, and genetics. Using an approach combining biochemistry, molecular biology, and genetics, Nussenzweig and his team focus on B lymphocytes and antibodies to HIV-1 in their work on adaptive immunity, while their studies of innate immunity focus on dendritic cells.

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